Thousands saw their travel plans in the Caribbean upended over the weekend after the US launched a series of airstrikes in Venezuela and captured former dictator Nicolas Maduro.

US Secretary of Transportation Sean Duffy closed off the airspace in the region on Saturday night, with service still slow to return Sunday. Many flights were in limbo in the aftermath of the American military operation.

Derek Faktor, a dentist with offices in New York and New Jersey, told The Post his family was “essentially trapped” on Saint Kitts and Nevis, east of Puerto Rico, until Jan. 15 due to the situation.

“Our infant daughter is a bit ill and we are managing the best we can, but United Airlines has no outbound flights till Jan. 15th,” Faktor said.

“They have not sent any additional rescue flights for so many stranded people here, it’s not making any sense.”

Following Duffy’s orders, hundreds of flights were canceled to and from Puerto Rico, the Virgin Islands, Aruba and more than a dozen other destinations in the Lesser Antilles island group north of Venezuela.

Puerto Rico was among the hardest hit, with nearly 60% of all flights — more than 300 — to and from the Luis Muñoz Marín International Airport in San Juan canceled on Saturday.

Airlines are now scrambling to help their trapped passengers, with American, United and Delta Air Lines all scheduling additional flights on Sunday across the Caribbean.

Carriers have even weighed using larger planes, like ones used for Europe and Asia trips, to accommodate the weekend surge in demand as even new flights listed on Sunday morning sold out in a flash, CNBC reported.

The airlines have also waived change fees and fare differences for travelers affected by the closures.